Advanced understanding of toxicology in the occupational environment. Analysis of target organs, adverse health effects, and the systems/organs that are the targets of toxicants. Includes assessments of safety and risk of carcinogenic andnon-carcinogenic chemicals.
Course Textbook
Kacew, S., & Lee, B. M. (2013). Lu’s basic toxicology: Fundamentals, target organs, and risk assessment (6th ed.). New York, NY: Informa Healthcare.
Course Learning Outcomes
Upon completion of this course, students should be able to:
1. Compare and discriminate between the major sub-disciplines of toxicology and their roles in occupational safety and health.
2. Illustrate the mechanisms by which a toxicant passes through the cell membrane: routes of absorption, the distribution process, and routes of excretion of a toxicant.
3. Summarize and compare three types of Phase I reactions and the most common types of Phase II reactions.
4. Classify sub-cellular sites of action, types of molecular targets, and types of receptors that are responsible for being mediators of effects of toxins.
5. Compare and discriminate the different mechanisms of action that a toxin can use and the effects of chemical interactions among toxins.
6. Compare and discriminate the differences and similarities between chemical carcinogenesis, mutagenesis, and teratogenesis.
7. Summarize toxicants in human breast milk and adverse infant effects.
8. Discriminate common examples of toxins that affect the following systems or target organs in the human body: immune, respiratory, liver, kidney, skin, eye, nervous system, reproductive, and cardiovascular.
9. Describe the major toxicological concern of food additives, food contaminants, insecticides, metals, and over the-counter drugs on human health.
10.Summarize the toxic effects of common organic solvents, air pollutants, and water and soil pollutants.
11. Discriminate the toxic substances at workplaces and their toxic effects.
12. Explain the risk assessment procedures for non-carcinogenic and carcinogenic chemicals.

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